摘要：目的：研究白茅根多糖對(duì)糖尿病小鼠血脂代謝紊亂的調(diào)節(jié)作用。方法：首先采用腹腔注射鏈脲佐菌素( STZ )的方法構(gòu)建小鼠糖尿病模型，以鹽酸二甲雙胍為對(duì)照，觀察連續(xù)灌胃21d不同劑量白茅根多糖對(duì)糖尿病小鼠體重、甘油三酯（TG）、總膽固醇（TC）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）的含量和動(dòng)脈硬化指數(shù)（AI）的影響。結(jié)果：白茅根多糖可明顯改善糖尿病小鼠的血脂代謝紊亂的情況，能顯著地降低糖尿病小鼠體內(nèi)的TG、TC、LDL-C和AI、升高糖尿病小鼠的HDL-C的作用，其中高劑量白茅根多糖灌胃（200 mg/kg.d） 調(diào)節(jié)血脂代謝效果與臨床糖尿病治療藥物鹽酸二甲雙胍相當(dāng)。結(jié)論：白茅根多糖具有有效地調(diào)節(jié)糖尿病小鼠血脂代謝紊亂的活性。 

關(guān)鍵詞 白茅根多糖；糖尿病；血脂

Abstract:　Objective: The objective of this paper was to study the activities of Imperata Cylindrica Polysaccharides on blood lipids in diabetic mice. Method: Diabetes was induced by intraperitoneal injection of streptozotocin in mice. The changes of body weight, TC, TG, LDL-C, and HDL-C, and AI of mice were examined. Results: The blood lipids of diabetic mice were significantly ameliorated by Imperata Cylindrica polysaccharides. Compared with diabetic mice group, the levels of TC, TG LDL-C and AI of Imperata Cylindrica polysaccharides group were significantly decreased, and the level of HDL-C remarkably increased. The effects of improvement induced by high dose Imperata Cylindrica polysaccharides were as same as metformin hydrochloride group. Inclusion: Imperata Cylindrica polysaccharides could effectively ameliorate the levels of blood lipids of diabetic mice.

Keywords  Imperata Cylindrica Polysaccharides  Diabetes  Blood lipids